Research

Analysis of biomarkers in research projects, collaborations
 
We perform analyses for research projects, both for academic and commercial studies. Prices for analyses depend on number and type of samples, type of analysis, etc. Click the Contactbutton on the left hand side to inquire about the possibilities.
Our research
 

The neurochemical research group is headed by Dr. Marcel Verbeek. 

We continuously develop and  validate novel biomarker assays for application in neurochemical diagnosis. Click the News button for recent developments from our lab.
 
Overview of current projects in our group.
  
 
Our research group
 
Click the name to get information on the research projects
 
Dr. Marcel Verbeek: Alzheimer's disease, Parkinson's disease, Biomarkers, Cerebrospinal Fluid [CSF], Cerebral Amyloid Angiopathy, inflammation
 
Dr. Bea Kuiperij: Biomarkers for Alzheimer's Disease, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Inclusion Body Myopathies.
 

Drs. Elisanne Biemans: Alzheimer's disease, transport of amyloid beta protein, blood-brain barrier, apolipoproteins
 
Drs. Linda van Waalwijk van Doorn: Biomarkers, Alzheimer's Disease, Parkinson's Disease, Cerebrospinal Fluid
 
Drs. Anouke van Rumund: Parkinson's disease, biomarkers, atypical Parkinsonism, cerebrospinal fluid, diagnosis, MRI

Drs. Sharon Ooms:  Alzheimer's disease, biomarkers, diurnal fluctuation, sleep, amyloid beta protein, tau proteins, cerebrospinal fluid

Drs. Taina Marques Macherini: Parkinson's disease, miRNAs, cerebrospinal fluid, proteomics

 
Posters of our research group
 
Download posters presented at AD/PD Conference in Florence, Italy; March 2013.
 
Download posters presented at AAIC 2012 (Alzheimer's Association International Conference) in Vancouver, Canada.
 
 Download posters presented at ICAD 2011 (International Conference on Alzheimer's Disease) in Paris, France.
 
Download posters presented at the AD/PD meeting In Barcelona, Spain, 2011.
 
 
 
Previous members of our research group

Dr. Diane Slats: Alzheimer's disease, biomarkers, diurnal fluctuation, sleep, amyloid beta protein, tau proteins, cerebrospinal fluid

Dr. Petra Spies: Alzheimer's Disease, cerebrospinal fluid, biomarkers, amyloid beta protein, tau proteins, cognition

 
 
Dr. Danielle de Jong
 
 
Dr. Annemieke Rensink
 
Dr. Jose Vis

Dr. Nienke TimmerAlzheimer’s disease, glutamatergic neurotransmission, transgenic mouse models, amyloid b protein
 
Dr. Ilona BruinsmaAlzheimer’s disease, amyloid β protein, Parkinson’s disease, α-synuclein protein, Multiple Sclerosis, microRNAs
 
Dr. Kim BrugginkAlzheimer’s Disease, Amyloid β protein, Cerebrospinal Fluid (CSF).
 
Dr. Mareike MullerAlzheimer’s Disease, biomarkers, miRNA

Drs. Marjolein Aerts: Parkinson's disease, biomarkers, atypical Parkinsonism, cerebrospinal fluid, diagnosis, MRI

Dr. Megan Herbert BAppSc: Alzheimer's disease, oxidized proteins, biomarkers, PIN-1, glutamine synthetase

 
 
Latest publications

miRNA analysis in CSF:

Müller M, Kuiperij HB, Versleijen AA, Chiasserini D, Farotti L, Baschieri F, Parnetti L, Struyfs H, De Roeck N, Luyckx J, Engelborghs S, Claassen JA, Verbeek MM. Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study. J Alzheimers Dis. 2016;52(4):1321-33.

Müller M, Jäkel L, Bruinsma IB, Claassen JA, Kuiperij HB, Verbeek MM. MicroRNA-29a Is a Candidate Biomarker for Alzheimer's Disease in Cell-Free Cerebrospinal Fluid. Mol Neurobiol. 2016;53(5):2894-9. 

Müller M, Kuiperij HB, Claassen JA, Küsters B, Verbeek MM. MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid. Neurobiol Aging. 2014;35(1):152-8.

Müller M, Claassen JA, Kuiperij HB,Verbeek MM. Cerebrospinal fluid NrCAM is not a suitable biomarker to discriminate between dementia disorders – A pilot study. J Alzh Dis. 2015;46:605-609.

CSF Biomarker studies:
Verbeek MM, Leen WG, Willemsen MA, Slats D, Claassen JA. Hourly analysis of cerebrospinal fluid glucose shows large diurnal fluctuations. J Cereb Blood Flow Metab. 2016;36(5):899-902.

Biemans EA, Verhoeven-Duif NM, Gerrits J, Claassen JA, Kuiperij HB, Verbeek MM. CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.

Neurobiol Aging. 2016 Jun;42:213-6.


van Waalwijk van Doorn LJ, Koel-Simmelink MJ, Haußmann U, Klafki H, Struyfs H, Linning P, Knölker HJ, Twaalfhoven H, Kuiperij HB, Engelborghs S, Scheltens P, Verbeek MM, Vanmechelen E, Wiltfang J, Teunissen CE. Validation of soluble amyloid-β precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases. J Neurochem. 2016 Apr;137(1):112-21


Simonsen AH, Kuiperij B, El-Agnaf OM, Engelborghs S, Herukka SK, Parnetti L, Rektorova I, Vanmechelen E, Kapaki E, Verbeek M, Mollenhauer B. The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature. Biomark Med. 2016;10(1):19-34


Herbert MK, Verbeek MM, Küsters B, Kuiperij HB. A multifunctional ELISA to measure oxidised proteins: oxPin1 in Alzheimer's brain as an example. BBA Clinical. 2015;4:1-6


Herbert MK, Aerts MB, Beenes M, Norgren N, Esselink RAJ, Bloem BR, Kuiperij HB, Verbeek MM. CSF neurofilament light chain but not FLT3 ligand discriminates Parkinsonian disorders. Frontiers in Neurology. 2015;6: 00091.


Alzheimer's disease:

Bruggink KA, Kuiperij HB, Gloerich J, Otte-Höller I, Rozemuller AJ, Claassen JA, Küsters B, Verbeek MM. Dickkopf-related protein 3 is a potential Aβ-associated protein in Alzheimer's Disease. J Neurochem. 2015;134(6):1152-62.


   
Continuous collection of CSF (24-36 hours)

We have developed the technique for the continuous collection of Cerebrospinal Fluid in humans. This technique offers many opportunities for testing drug efficacy and research projects.
In collaboration with the Alzheimer Centre Nijmegen, we have developed the methodology to collect serial CSF samples using indwelling catheters. This unique technology allows for continuous monitoring of CSF components and / or of active compounds and is thus an excellent tool for application in drug intervention studies.
Click here for more information on these projects.