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Alzheimer's disease

The cerebrospinal fluid (CSF) of Alzheimer's disease patients contains increased levels of total tau protein (t-tau) and phosphorylated tau (p-tau) protein, and decreased levels of the amyloid beta42 (Abeta42) protein as compared to neurological controls. Amyloid beta40 (Abeta40) protein levels are usually normal or (slightly) decreased when there is vascular comorbidity, e.g. in the form of Cerebral Amyloid Angiopathy.

In many studies the use of CSF analysis of t-tau, p-tau and Abeta42 has been demonstrated to discriminate AD from non-AD dementia. Besides, patients with Mild Cognitive Impairment (MCI) and an "AD-CSF pattern" are at high risk to develop AD later in life. Therefore, it has become increasingly accepted to analyse the CSF in cases with uncertainty about the type of dementia disorder.

 

Our laboratory offers fast and efficient analysis of the following compounds in CSF for the diagnosis of Alzheimer's disease:
- t-tau protein
 
- p-tau protein
 
- Amyloid beta40 protein
 
- Amyloid beta42 protein
 
In addition we offer an assay to analyse Amyloid beta protein oligomers in CSF
 
Click here to download protocols.
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