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Angiitis and vasculitis

Primary angiitis comprises the rare disorder of inflammation of the CNS vasculature without involvement of peripheral vessels. Symptoms may include headache, cognitive dysfunction, chronic & aseptic meningitis, stroke (TIA).
Inflammatory findings in the Cerebrospinal Fluid (CSF):
- Lymphocytic pleocytosis (median CSF cel count <20 [0–575] cells/uL)
- Normal glucose
- Increased total protein (median CSF protein concentrations <120 ([50–10340] mg/L)

Wegener's granulomatosis. Abnormal CSF findings include:
- Increased cell count (in 40% of the patients)
- Increased total protein (in 40% of the patients)
- Increased CSF pressure (in 17% of the patients)
CSF is normal in approximately 30% of patients.

CSF findings in Neuro-Behcet:
- I
ncreased CSF pressure
- Mildly increased cell count (usually granulocytes) and total protein
- Unique oligoclonal IgG bands in 10-50% of patients



Sjogren's disease. Little is known about CSF findings in this disorder, but may include:
- A mildly increased cell count (lymfocytes, monocytes)
-
Unique oligoclonal IgG bands in up to 80% of patients
- Intrathecal IgM production in up to 80% of patients


In Neuro-SLE, CSF findings may include:
- Cell count is often normal and increased (< 100 / uL) in up to 25% of patients
- Total protein is often normal and increased in up to 25% of patients
- Glucose and lactate are normal
-
Unique oligoclonal IgG bands in up to 25-50% of patients

Amyloid
-β related angiitis

See Cerebral Amyloid Angiopathy page.

Our laboratory offers fast and efficient analysis of the following compounds in CSF for the diagnosis of Angiitis and Vasculitis:

- Routine CSF analysis (cell count & differentiation), glucose, lactate, total protein
 
-Oligoclonal IgG bands by iso-electric focussing & immundetection
 
- Quantitative intrathecal synthesis of IgG, IgA and IgM
 
 
Click here to download analysis protocols.
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