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Multiple Sclerosis

Typical CSF findings in Multiple Sclerosis comprise:

- Slightly elevated cell count (usually lymfocytes, < 30 / uL)
- Normal glucose, lactate
- Slightly elevated total protein

Specific findings in CSF from Multiple Sclerosis:

- Unique oligoclonal IgG bands in CSF
- Intrathecal IgG production

- Intrathecal IgM production predict a more aggressive disease in RR-MS, but not PP-MS
- Increased concentrations of Myelin Basic Protein (MBP) in CSF

Our laboratory offers fast and efficient analysis of the following compounds in CSF for the diagnosis of ADEM:

- Routine CSF analysis (cell count & differentiation), glucose, lactate, total protein
-Oligoclonal IgG bands by iso-electric focussing & immundetection (requires both CSF and serum analysis)
- Quantitative intrathecal synthesis of IgG, IgA and IgM (requires both CSF and serum analysis, also of albumin)

Click here to download analysis protocols.