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Neuro-sarcoidosis

Cerebrospinal Fluid (CSF) findings in patients with neuro-sarcoidosis include:

- Increased cell count (lymfocytes; 50-200 / uL)
- Decreased glucose
- (Strongly) increased lactate
- (Strongly) increased total protein
- Unique oligoclonal IgG bands in 50% of patients (often in combination with a number of oligoclonal IgG bands that are found in both CSF and serum)
- No intrathecal IgA and IgM synthesis

- Please note: analysis of ACE in CSF has low sensitivity and specificity

Our laboratory offers fast and efficient analysis of the following compounds in CSF for the diagnosis of Neuro-sarcoidosis:

- Routine CSF analysis (cell count & differentiation), glucose, lactate, total protein
 
-Oligoclonal IgG bands by iso-electric focussing & immundetection (requires both CSF and serum analysis)
 
- Quantitative intrathecal synthesis of IgG, IgA and IgM (requires both CSF and serum analysis, also of albumin)

 
Click here to download protocols.
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