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Neuroborreliosis

Typical findings in CSF in neuroborreliosis comprise:


- Elevated cell count, usually lymfocytes and monocytes
- Normal concentrations of glucose and lactate
- Increased total protein concentration

Specific abnormalities, that discriminate neuroborreliosis from other disorders:
- Intrathecal IgM production in 80% of cases
- Unique oligoclonal IgG bands in CSF (as detected by IEF + immunblotting)

- Increased concentrations of the chemokine CXCL13. Levels are much higher than in any other neuro-inflammatory disease, and drop after appropriate treatment.
Therefore, this is an excellent biomarker to diagnose neuroborreliosis. PubMed CXCL13.

Refer to the Search Analysis page to obtain more information on these biomarkers.

Our laboratory offers fast and efficient analysis of the following compounds in CSF for the diagnosis of Neuroborreliosis:

- Routine CSF analysis (cell count & differentiation), glucose, lactate, total protein
 
-Oligoclonal IgG bands by iso-electric focussing & immundetection (requires both CSF and serum analysis)
 
- Quantitative intrathecal synthesis of IgG, IgA and IgM (requires both CSF and serum analysis, also of albumin)

- CXCL13
 
 
Click here to download analysis protocols.
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