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Poly(radiculo)neuropathies

Cerebrospinal fluid (CSF) investigations in Poly(radiculo)neuropathies, such as in patients with Guillain-Barre Syndrome (GBS) or Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP), generally comprise the following signature:

- Normal CSF cell count (i.e. < 4 per uL; in 2% of case > 10 per uL)
- Increased total protein in CSF or increased Albumin [CSF] / Albumin [serum] ratio
- Frequently, a "mirror" pattern of oligoclonal IgG bands in CSF and serum is observed (i.e. the same oligoclonal IgG bands in both body fluids)

In specific syndromes, an association with the occurence of anti-ganglioside antibodies in serum can be found:

- In Miller - Fisher syndrome (characterised by ophthalmoplegia, ataxia and areflexia), serum antiGQ1b antibodies are found in 80-90% of patients. The titer decreases rapidly after appropriate treatment
- In CMV-associated GBS, anti-GM2 antibodies are found
- In Camylobacter jejuni-associated GBS, anti-GM1, anti-GM-1b, anti-GD1a and anti-GalNAc-GD1a antibodies are foun
- In Multifocal Motor Neuropathy, in 50% of patients anti-GM1 antibodies are observed


Our laboratory offers fast and efficient analysis of the following compounds in CSF for the diagnosis of Neuroborreliosis:

- Routine CSF analysis (cell count & differentiation), glucose, lactate, total protein
 
- Oligoclonal IgG bands by iso-electric focussing & immundetection (requires both CSF and serum analysis)
 
- Quantitative intrathecal synthesis of IgG, IgA and IgM (requires both CSF and serum analysis, also of albumin)

- Anti-GM1, anti-GM2 and anti-GQ1b antibodies in serum
 
 
Click here to download analysis protocols.
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